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KMID : 0381219710030100729
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Journal of RIMSK
1971 Volume.3 No. 10 p.729 ~ p.734
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BRONCHODILATOR EFFECTS OF β-ADRENERGIC AGENTS ON ASTHMATICS ADMINISTERED BY AEROSOL INHALATION
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Abstract
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The purpose of this paper is to compare the bronchodilator activities and the cardiovascular activities of three beta-adrenergic stimulants(isoproterenol, metaproterenol and salbutamol) in asthmatic patients when each preparation was administered in dry aerosols from the nebulizers.
It is thus reasonable to conclude that in asthmatic subjects salbutamol does not cause betaadrenergic cardiac effects, but nevertheless produces clinically useful improvement in reversible airways obstruction. In guinea pigs salbutamol is shown to be a hundred times more potent stimulant of adrenergic beta2-receptors than metaproterenol and there is also evidence in animals that salbutamol is much less active on beta, receptors than metaproterenol and isoproterenol. Under these circumstances, many reports suggest that salbutamol, given by aerosol inhalation. may prove to be the most effective and safest aerosol available for the relief of acute asthmatic symptoms.
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KEYWORD
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